ABCR Gene and Age-Related Macular Degeneration
نویسندگان
چکیده
منابع مشابه
ABCR Gene and Age-Related Macular Degeneration
Stargardt disease is a recessively inherited degeneration of the macula of the retina arising in youth (usually in teenagers and young adults) that is caused by defects in the ABCR gene (1). Rando Allikmets et al. investigate (2) the idea that heterozygote carriers of ABCR mutations might develop age-related macular degeneration (AMD) late in life. We wish to point out methodological deficienci...
متن کاملMolecular genetic analysis of ABCR gene in Japanese dry form age-related macular degeneration.
PURPOSE To explore whether the mutation in the retina-specific ATP-binding cassette transporter (ABCR) gene, the Stargardt's disease gene, contributes to the prevalence of the dry form of age-related macular degeneration (dry AMD) in Japanese unrelated patients. METHODS Twenty-five Japanese unrelated patients with dry AMD who were diagnosed by fluorescein angiography and indocyanine green ang...
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Background & Aims: To investigate the association of CFI p.Gly119Arg polymorphism with Age-related macular degeneration (AMD). Materials & Methods: In this case-control study, the association of p.Gly119Arg polymorphism in CFI gene was investigated in 65 patients suffering from AMD and150 healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and cont...
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amd بیماری تحلیل شبکیه است که عامل اصلی کوری در افراد بالای 55 سال در جهان غرب به شمار می-رود. در اثر این بیماری، لیپوپروتئین ها در شبکیه تجمع پیدا کرده و رگ زایی القاء می شود. ثابت شده است که عوامل ژنوتوکسیک محیطی مثل سیگار کشیدن، رژیم غذایی و نور در افراد پیر با زمینه ی ژنتیکی مستعد در بروز بیماری دخیل می باشند. بنابراین ما یک مطالعه ی مـورد- شاهـدی را ترتیب دادیم که شـامل 112 فرد مبتلا به am...
the genetics of age-related macular degeneration
age-related macular degeneration (amd) is the leading cause of blindness in old subjects. it is a multifactorial disease with both environmental and genetic factors playing some role in its pathogenesis. similar to many other genetic diseases, the inheritance pattern of amd does not fit into simple mendelian rules. these diseases are caused by the presence of multiple genetic factors and are ca...
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ژورنال
عنوان ژورنال: Science
سال: 1998
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.279.5354.1107a